Authors: Anna F. Dominiczak, David F. Bohr
From the Department of Medicine and Therapeutics, University of Glasgow (Scotland) (A.F.D.), and the Department of Physiology, University of Michigan, Ann Arbor (D.F.B.).
Correspondence to David F. Bohr, MD, Department of Physiology, University of Michigan, Ann Arbor, MI 48109-0622.
- Key Words:
- nitric oxide
- hypertension, arterial
- endothelium-derived factors
- vasodilator agents
- nitro compounds
- blood vessels
In the past 5 years, nitric oxide (NO) has become recognized as a major player in most physiological and pathophysiological processes. So much has been learned about the involvement of this molecule in these processes that it seems appropriate to survey the current state of this insight, with the goal of creating a solid foundation on which these studies can continue. In this review we deal first with the basic metabolism and actions of NO, emphasizing aspects of the subject that may have bearing on hypertension. We close with a review of studies that deal specifically with the involvement of NO in experimental and clinical hypertension. The involvement cannot now be clearly defined; however, this survey indicates that promising insights are within reach.